Frontier Medicines is seeking two Sr. Clinical Trial Managers to support the day-to-day execution of our oncology clinical trials as they advance through clinical development. Working under the guidance of our Sr. Director, Clinical Operations, you will serve as a key operational contact for our CROs and trial sites, helping drive feasibility assessments, site selection, start-up, maintenance, and close-out.
This is a great opportunity for someone who wants hands-on ownership of trial execution at a growing, clinical-stage biotech, with direct exposure to program strategy and cross-functional leadership. This is a hybrid role based in our Boston, MA office, with an expectation of 2-3 days per week onsite, plus periodic travel to trial sites and CRO/vendor meetings as needed.
Requirements
What will you be doing?
● Support day-to-day activities within one or more clinical trials, including country/site feasibility assessments, site selection, start-up, maintenance, and close-out.
● Serve as a key operational point of contact for CROs and trial sites, identifying and escalating potential issues as needed.
● Assist with oversight of CRO and vendor set-up, liaising with CROs to ensure timely study initiation.
● Review site-level regulatory documents (e.g., Informed Consent Forms, essential documents) and escalate to appropriate stakeholders as needed.
● Help ensure inspection readiness, TMF quality, and adherence to protocol and regulatory requirements.
● Proactively identify potential operational challenges and, in partnership with senior team members, propose mitigation plans to keep study execution on track.
● Assist with review of protocols, master template informed consent forms, case report forms, and other clinical study documents as needed.
● Monitor study performance metrics, timelines, and deliverables, and review CRO trip reports for trends and quality issues.
● Track study budgets and vendor invoices/change orders in partnership with Clinical Operations and Finance, flagging discrepancies as needed.
● Help maintain timely and accurate study registration and updates on ClinicalTrials.gov and other applicable registries.
● Coordinate Clinical Trial Team meetings and drive action item follow-up.
● Maintain clinical operations trackers, databases, and document repositories.
● Provide regular study updates to internal stakeholders and support enrollment, database lock, and study closeout activities.
Traits we believe make a strong candidate:
● Bachelor's degree in a scientific, healthcare, or related field, or an RN, required.
● 5-7 years of Clinical Trial Manager/SCTM or Clinical Project Management experience, ideally supporting oncology clinical trials.
● Experience supporting oncology studies strongly preferred.
● Vendor and CRO management experience.
● Strong working knowledge of ICH-GCP guidelines and clinical trial regulations.
● Excellent organizational, problem-solving, and time management skills, with strong attention to detail.
● Strong written and verbal communication skills with a collaborative, team-oriented approach.
● Comfortable in a fast-paced, dynamic environment; a proactive, roll-up-your-sleeves mindset.
● Legally authorized to work in the United States.
Benefits
At Frontier, we strive to build a diverse and equitable workplace. The salary range for this role is $125,000 - $170,000. Compensation for the role will depend on a number of factors, including candidates' qualifications, skills, competencies and experience. Frontier offers a competitive total rewards package which includes healthcare coverage, 401k and a broad range of other benefits.
This compensation and benefits information is based on Frontier's knowledge as of the date of publication, and may be modified in the future.
The Sr. Clinical Trial Manager is responsible for overseeing Ascendis' global and regional clinical trials, ensuring compliance and effective collaboration among cross-functional teams.
Supervisors are responsible for ensuring that every associate clinician operates within clinical, regulatory, and organizational standards, while maintaining alignment with Impireum’s whole-person care model.
The Senior Clinical Development Analyst will assist in the preparation and review of clinical and non-clinical documentation for regulatory submissions and contribute to clinical strategy discussions.
The Senior Manager, Clinical Supply will lead clinical demand and supply planning, ensuring sufficient vaccine and comparator supply for trials while managing packaging runs and logistics.
The Associate Director/Director of Clinical Operations Compliance will oversee adherence to standard procedures, support issue management, and ensure clinical programs are inspection ready.
