Senior Director, Quantitative Systems Pharmacology – Oncology (Hybrid or Remote)

We are seeking an accomplished scientific leader to join the Quantitative Pharmacology and Pharmacometrics –Oncology (QP2 Oncology) team as Senior Director, Quantitative Systems Pharmacology (QSP).

Description

• Lead and shape the QSP strategy across the oncology portfolio, ensuring alignment with program goals and organizational priorities.
• Lead, mentor, and develop a team of quantitative scientists in a matrixed role.
• Work in close collaboration with QP2 Oncology team, preclinical DMPK and modeling teams, biologists, clinicians, and other line functions to utilize mechanistic/ QSP modeling for dose selection, combination strategies.
• Ensure high-quality, regulatory grade QSP deliverables for internal decisions, submissions, and scientific advice meetings.
• Contribute to regulatory strategy through preparation of QSP reports, briefing documents, and presentations.
• Foster a culture of scientific rigor, excellence, collaboration, and innovation and develop best practices for QSP modeling.

Requirements

• Ph.D. with at least ten years of pharmaceutical drug development experience or Masters/PharmD with at least fifteen years of experience.
• Extensive experience in developing mechanistic PK-PD models and QSP models for decision making in clinical development.
• Demonstrated ability to lead an interdisciplinary team or taskforce.
• Oncology therapeutic area or disease knowledge.
• Experience with mechanistic modeling for antibody drug conjugates (ADCs) and/or T-cell engagers.
• Experience with modeling and simulation packages or programming languages (e.g., MATLAB, R, SimBiology, Python).
• Experience working with external QSP vendors.
• Proficiency in written and verbal communication, interdisciplinary collaboration, and problem scoping and planning.

Benefits

• Comprehensive package of medical
• Dental
• Vision healthcare and other insurance benefits for employee and family
• Retirement benefits, including 401(k).
• Paid holidays
• Vacation
• Compassionate and sick days